An increased cortisol level, a decreased DHEA-S level, or a decrease in the DHEA-S cortisol ratio is an indication of a chronically stressful physical or mental condition.Stress is a major underlying cause of many chronic illnesses, from Chronic Fatigue Syndrome to food and environmental allergies. A stressful lifestyle can lead to consistently high levels of cortisol and low levels of DHEA (dehydoepiandosterone), which can be damaging to the brain and other tissues. Cortisol elevation also impacts immune responses, such as secretory IgA (sIgA) and antigliadin antibody (AGA) production. The Adrenal Stress Profile is a measure of an individual’s response to stress. It is also an important tool for pointing to adrenal imbalances that may be impacting a patient’s health.

The adrenocortical hormones, cortisol and DHEA, are steroids that affect carbohydrate, protein, and lipid metabolism. They also serve as modulators of thyroid function and help the body manage stress. When levels of DHEA and cortisol change, it may indicate significant variations in adrenal function that can impact an individual’s energy levels, emotions, and even disease resistance.

When the Adrenal Stress Profile indicates an inappropriate hormonal stress response, it is necessary to consider stress reduction through diet and lifestyle modification, and nutritional supplementation to support adrenal gland activity and enhance the restoration of the physical barrier in the gut

How Adrenal Glands Work

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